Author(s):
Karthic R, Andrews B, Subramani K
Email(s):
karthicrm@gmail.com
DOI:
10.5958/0974-4150.2017.00018.9 
Address:
Karthic R1*, Andrews B2, Subramani K1
1PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635751, India
(Affiliated to Thiruvalluvar University, Vellore, Tamil Nadu, India)
2Department of Chemistry, Priyadarshini Engineering College, Vaniyambadi, India
(Affiliated to Anna University, Chennai, Tamil Nadu, India)
*Corresponding Author
Published In:
Volume - 10,
Issue - 2,
Year - 2017
ABSTRACT:
Simple synthetic methods of 5-(5-amino-1,3,4-thiadiazol-2yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc.H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antifungal activity. Most of the tested compounds show significant antifungal activity.
Cite this article:
Karthic R, Andrews B, Subramani K. Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds. Asian J. Research Chem. 2017; 10(2):119-123. doi: 10.5958/0974-4150.2017.00018.9
Cite(Electronic):
Karthic R, Andrews B, Subramani K. Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds. Asian J. Research Chem. 2017; 10(2):119-123. doi: 10.5958/0974-4150.2017.00018.9 Available on: https://ajrconline.org/AbstractView.aspx?PID=2017-10-2-7