Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Reverse Phase High Performance Liquid Chromatography for Method Development Validation of Omeprazole in Bulk and Pharmaceutical Dosage Form

Author(s): Rajan V. Rele, Prathamesh P. Tiwatane

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-4150.2018.00051.2   

Address: Rajan V. Rele, Prathamesh P. Tiwatane
Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai , 400 016.
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2018

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ABSTRACT:
The validation of omeprazole from combined dosage form i.e. tablets was described by high performance liquid chromatography method with separation of drugs on BDS Hypersil C18 (150 x 4.6 mm i.d.) and 5 µ particle size. A mixture of buffer and acetonitrile (65:35 % (v/v)) was constituted as mobile phase. The chromatograms were studied at 230 nm as wavelength. The mobile phase was also used as a diluent. A validated of method was studied for linear regression, accuracy, method as well as system precision. The robustness study was done for change in wavelength, mobile phase composition and flow rate as per ICH guidelines. The method has been successfully used to analyze omeprazole from dosage form i.e. tablets and drotaverine from combined dosage form i.e. tablets.


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Cite this article:
Rajan V. Rele, Prathamesh P. Tiwatane. Reverse Phase High Performance Liquid Chromatography for Method Development Validation of Omeprazole in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 2018; 11(2):275-278. doi: 10.5958/0974-4150.2018.00051.2


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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DOI: 10.5958/0974-4150 

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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