ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): K. Vijaya Sri, M. A. Madhuri, M. Prajwala

Email(s): Email ID Not Available

DOI: 10.5958/0974-4150.2018.00100.1   

Address: K. Vijaya Sri*, M. A. Madhuri, M. Prajwala
Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, (Affiliated to Osmania University) Maisammaguda, Secunderabad-500 100
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
The main objectives of presented work were developed and validate the UV-spectrophotometric and RP-HPLC method for the estimation Imatinib as per ICH guidelines in bulk and pharmaceutical dosage form. In UV-spectrophotometric and HPLC method was developed by using solvent Acetonitrile and water in the ratio of 50:50 (%v/v). The RP-HPLC method was developed in Symmetry C18(4.6 x 150mm, 5?m). In UV-spectrophotometric method, the optimal response for two of them was obtained at 242 nm. Hence, the ?max of UV and HPLC for Imatinib was 242 nm were found to be respectively. It was proved that linearity in the concentration range for Imatinib was 0.5-3 µg/ml and for HPLC the linearity range between 0.25-1.5µg/ml for Imatinib 0.5-3 µg/ml with a correlation coefficient value of 0.999. The % RSD for intraday precision and interday precision was less than 2% for UV-spectrophotometric and RP-HPLC method. A new, simple, economic and accurate UV-spectrophotometric and RP-HPLC method were developed for the estimation of Imatinib in the bulk and in the pharmaceutical dosage form.


Cite this article:
K. Vijaya Sri, M. A. Madhuri, M. Prajwala. Validation of UV Spectrophotometric and HPLC Methods for quantitative determination of Imatinib in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 2018; 11(3):555-562. doi: 10.5958/0974-4150.2018.00100.1


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