ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Mahwish Fatima, Bharath Rathna Kumar. P, Venu Priya. R, Sunil Kumar Kadiri

Email(s): bharathpharm@gmail.com

DOI: 10.52711/0974-4150.2024.00014   

Address: Mahwish Fatima1, Bharath Rathna Kumar. P1*, Venu Priya. R1, Sunil Kumar Kadiri2
1Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Telangana, India.
2Department of Pharmacology, College of Pharmaceutical Sciences, Dayanand Sagar University, Karnataka, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2024


ABSTRACT:
Synthesis, characterization of a series of some new antipyrine derived Schiff bases 5(a-f) have been carried out and evaluated for their antioxidant activity. The newly synthesized compounds were characterized by physical and spectral data. The compounds 5(a-f) were measured for physical parameters and enlisted. The completion of the reaction, the progress of the reaction, and the purity of all newly produced compounds were monitored by TLC. Compounds in series 5(a-f) have yields that vary from 70 to 93%. Based on a review of the literature, there were no antipyrine derivatived Schiff bases reported till now, hence they were synthesized and characterized in this work. It was found that these moieties were useful in the field of pharmaceutical chemistry and that they demonstrated a variety of pharmacological actions. In the current work, six synthetic compounds 5(a-f) were prepared, and characterized by FTIR, 1HNMR and Mass spectroscopy studies. Melting points were determined and TLC was used to verify the purity of each compound. In an effort to produce new therapeutic compounds these compounds are tested for antioxidant properties and reported.


Cite this article:
Mahwish Fatima, Bharath Rathna Kumar. P, Venu Priya. R, Sunil Kumar Kadiri. Synthesis, Characterization and Antioxidant Activity of some New Antipyrine derived Schiff Bases. Asian Journal of Research in Chemistry. 2024; 17(2):73-7. doi: 10.52711/0974-4150.2024.00014

Cite(Electronic):
Mahwish Fatima, Bharath Rathna Kumar. P, Venu Priya. R, Sunil Kumar Kadiri. Synthesis, Characterization and Antioxidant Activity of some New Antipyrine derived Schiff Bases. Asian Journal of Research in Chemistry. 2024; 17(2):73-7. doi: 10.52711/0974-4150.2024.00014   Available on: https://ajrconline.org/AbstractView.aspx?PID=2024-17-2-2


REFERENCES:
1.    C. J. Patil, Manisha C. Patil, Mrunmayee C. Patil. Studies on Synthesis of Aromatic Schiff Bases. Part-V. Evaluation of Antifungal Potential of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone. Research J. Science and Tech. 2018; 10(2): 125-130.
2.    Okey, N.C. Obasi, N.L. Ejikeme, P.M. Ndinteh, D.T. Ramasami, P. Sherif, E.-S.M. Akpan, E.D. Ebenso, E.E. Evaluation of some amino benzoic acid and 4-aminoantipyrine derived Schiff bases as corrosion inhibitors for mild steel in acidic medium: Synthesis, experimental and computational studies. J. Mol. Liq. 2020; 315: 113773
3.    B. R. Thorat, M. Mustapha, D. Khandekar, Swati Lele, P. Kamat, S. Sawant, R. Jadhav, D. Shelke, Shivaji Kolekar, R. G. Atram, R. Yamgar. Synthesis and Fluorescence Properties of Schiff Bases of 2-chloro-3-formylquinoline. Research J. Pharm. and Tech. 2012; 5(3): 369-375.
4.    Catalano, A. Sinicropi, M.S. Iacopetta, D. Ceramella, J. Mariconda, A. Rosano, C. Scali, E. Saturnino, C. Longo, P. A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents. Appl. Sci. 2021; 11: 6027.
5.    Ram Vishun Prasad, Ashutosh Singh. Synthesis, Characterization, Antibacterial and Antifungal study of Novel Co (II) metal complexes of bidentate 3-Formylchromone based Schiff bases. Asian Journal of Pharmaceutical Research. 2022; 12(3): 203-6.
6.    Murtaza, G. Mumtaz, A. Khan, F.A. Ahmad, S. Azhar, S. Najam-Ul-Haq, M. Atif, M. Khan, S.A. Maalik, A. Alam, F. et al. Recent pharmacological advancements in Schiff bases: A Review. Acta Pol. Pharm.-Drug Res. 2014; 71: 531–535.
7.    Kajal, A. Bala, S. Kamboj, S. Sharma, N. Saini, V. Schiff Bases: A Versatile Pharmacophore. J. Catal. 2013; 2013: 893512.
8.    S. K. Nimbal, Manjunath Patil, Pradeep Ronad, Pradeep Kumar MR. Evaluation of Analgesic activity of Schiff base Coumarins with metal complex. Research Journal of Pharmacy and Technology. 2023; 16(7): 3092-8.
9.    Teran, R. Guevara, R. Mora, J. Dobronski, L. Barreiro-Costa, O. Beske, T. Pérez-Barrera, J. Araya-Maturana, R. Rojas-Silva, P. Poveda, A. et al. Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine. Molecules. 2019; 24: 2696.
10.    Mermer, A. Demirbas, N. Uslu, H. Demirbas, A. Ceylan, S. Sirin, Y. Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies. J. Mol. Struct. 2019; 1181: 412–422.
11.    S. Subramanyam, Ramu Samineni, Sunil Kumar Kadiri, J. P. Yanadaiah, Phaneendranath Jonnalagedda, Krishna Veni Chikkula and Sampath A. Gouru, Synthesis and In-vivo Bioactivity Studies of Some New Hydrazide Schiff Bases and Mannich Bases of Indole Derivatives, Indian Journal of Heterocyclic Chemistry. 2023; 33: 299-309.
12.    Alok Pandey, Shekhar Verma, Ravindra Dhar Dubey, Dhansay Dewangan, Vidyanand Patel, Keshav Deshmukh. Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole. Asian J. Research Chem. 2011; 4(2): 278-281.
13.    A. Kaura, Lalit Sharma, V. J. Dhar. Spectral and Antimicrobial Study of Some Novel Schiff Bases and Beta-Lactam Derivatives. Research J. Pharm. and Tech. 2012; 5(1): 129-132.
14.    Mahdi F. Radi, Suhair S. Husain, Abrar Natek Mohammed Zaki, Ala`a A. Sultan, Wejdan Mahmmod Hamed, Wessal M. Khamis. Synthesis and Characterization of some new Schiff base Compounds derived from 4-Amino benzoic acid and study their Biological activity. Research J. Pharm. and Tech. 2019; 12(5): 2207-2212.
15.    Shaimaa A. Hassan, Sajid M. Lateef, Ismaeel Y. Majeed. Structural, Spectral and Thermal studies of new bidentate Schiff base ligand type (NO) derived from Mebendazol and 4-Aminoantipyrine and it's metal complexes and evaluation of their biological activity. Research J. Pharm. and Tech. 2020; 13(6): 3001-3006.
16.    Nadia Sadiq Majeed, Fatima Naeem Abdul-Hussein. Preparation, Identification and Evaluation of Biological Activity of some new β-Lactam compounds derived from Schiff bases. Research Journal of Pharmacy and Technology. 2023; 16(2): 593-6.
17.    S Srilakshmi and Raja Sundararajan, Design, in-silico studies, synthesis, characterization, and anticonvulsant activities of novel thiazole substituted oxazole derivatives, Rasayan Journal of Chemistry, 2022; 15 (1): 711-725.
18.    S. N. Battin, A. H. Manikshete, S. K. Sarasamkar, M. R. Asabe, D. J. Sathe. Synthesis, Spectral, Antibacterial, Antifungal and Anticancer activity Studies of Schiff bases Derived from O-Vanillin and Aminoquinolines. Asian J. Research Chem. 2017; 10(5): 660-668
19.    Aliye Gediz Erturk, Vedat Sekeroglu, Esra Yildirim, Gamze Dindaroglu, Zulal Atli Sekeroglu, Antipyrine derived-Schiff base copper complex: Synthesis, characterization, and in vitro evaluation, Inorganica Chimica Acta. 2022; 543.
20.    Naoto Uramaru, Hidenari Shigematsu, Akihisa Toda, Reiko Eyanagi, Shigeyuki Kitamura and Shigeru Ohta, Design, Synthesis, and Pharmacological Activity of Nonallergenic Pyrazolone-Type Antipyretic Analgesics, J. Med. Chem. 2010; 53: 8727–8733.
21.    T. Durai Ananda Kumar, N, Swathi. Experimental Organic and Medicinal Chemistry Principles and Practice, Pharmamed press. 2015: 132-134.
22.    J. Joseph, K. Nagashri, G. Ayisha Bibin Rani, Synthesis, characterization and antimicrobial activities of copper complexes derived from 4-aminoantipyrine derivatives, Journal of Saudi Chemical Society. 2013; 17: 285–294.
23.    Kumar PBR, Sunil Kumar K, Deepak S. Khobragadec, Venu Priya R, Krishna Veni C, S Srilakshmi and Prashant Tiwari, Synthesis, Characterization and biological investigations of Some new Oxadiazoles: In-vitro and In-Silico approach. 2024; 7: 101241.
24.    Singagari S, Sundararajan R. Novel pyrazole substituted oxazole derivatives: Design, in-silico studies, synthesis and biological activities. J Res Pharm. 2022; 26(3): 625-640.

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