Gummudavelly Sandeep, Y Sri Ranganath, S Bhasker, N Rajkumar
Gummudavelly Sandeep*1, Y Sri Ranganath2, S Bhasker3 and N Rajkumar4
1Department of Pharmacy, J.K.K.M.M.R.F. College of pharmacy, Komarapalayam-638 183, Namakkal, Tamilnadu, India.
2 Department of Pharmaceutical Chemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028. India.
3Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University,Warangal-506002. India.
4Department of Pharmachemistry, J.K.K.N. College of pharmacy, Komarapalayam-638 183, Namakkal, Tamilnadu, India.
* Corresponding Author
Volume - 2,
Issue - 1,
Year - 2009
A new series of 7–methoxy-4-methyl-8-[5-(substituted aryl)isoxazol-3-yl]–2H–benzopyran-2-ones were synthesized by
cyclisization of chalcones, 8–(2-substituted prop-2-ene)–7–methoxy–4-methyl–2H-benzopyran–2–ones with hydroxylamine hydrochloride. The chalcones were synthesized starting from 7-hydroxy–4–methyl coumarin in 4 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anti microbial and anti inflammatory activities; some of them exhibited significant activity.
Cite this article:
Gummudavelly Sandeep, Y Sri Ranganath, S Bhasker, N Rajkumar. Synthesis and Biological Screening of Some Novel Coumarin Derivatives. Asian J. Research Chem. 2(1): Jan.-March,2009;Page 46-48.