ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Uddandam Aruneswari, Sreerama Usha rani, M Aruna Devi, Galla Rajitha

Email(s): rajitha_galla@yahoo.com

DOI: Not Available

Address: Uddandam Aruneswari1, Sreerama Usha rani1, M Aruna Devi2 and Galla Rajitha1*
1Institute of Pharmaceutical Tech., Sri Padmavathi Mahila Visvavidyalayam (Women’s University), Tirupati-517 502
2Trinity College of Pharmaceutical Sciences, Karimnager, A.P., India
*Corresponding Author

Published In:   Volume - 4,      Issue - 2,     Year - 2011


ABSTRACT:
A series of 4-(substituted benzylidene)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)-2-phenyl -1H-imidazol-5(4H)-ones were synthesized by condensation of 4-benzylidene-2-phenyl-oxazol-5-one with 2-amino-5-phenyl-1,3,4-thiadiazoles in presence of sodium acetate in glacial acetic acid. The intermediate 4-benzylidene-2-phenyl-oxazol-5-ones were prepared by condensing benzaldehydes with benzoyl glycine in presence of acetic anhydride and sodium acetate. The chemical structures of synthesized compounds were confirmed by means of IR, 1H NMR. All the compounds (10-18) were screened for antibacterial and antioxidant activities. Among all, the compounds 12, 16 exhibited highest antibacterial activity against all the four strains. Compound 12 exhibited highest nitric oxide scavenging activity and most of these compounds showed significant DPPH scavenging activity.


Cite this article:
Uddandam Aruneswari, Sreerama Usha rani, M Aruna Devi, Galla Rajitha. Synthesis and Evaluation of Substituted Imidazolones for Antibacterial and Antioxidant Activities. Asian J. Research Chem. 4(2): February 2011; Page 257-259.


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