ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): C. C. Kurgat, J. K. Kibet, P. K. Cheplogoi, S. C. Limo, P. M. Kimani

Email(s): jkibet@egerton.ac.ke

DOI: 10.5958/0974-4150.2016.00035.3   

Address: C. C. Kurgat1, J. K. Kibet*1, P. K. Cheplogoi1, S. C. Limo2, and P. M. Kimani1
1Department of Chemistry, Egerton University P.O Box 536 - 20115, Egerton, Kenya
2Department of Physics, University of Eldoret, P.O. Box 1125-30100, Eldoret, Kenya
*Corresponding Author

Published In:   Volume - 9,      Issue - 5,     Year - 2016


ABSTRACT:
The popularity of tobacco use worldwide has kicked off one of the greatest clinical debates on human toxicology and public health in general. Accordingly, this study investigates some of the alkaloids in tobacco believed not only to be addictive and carcinogenic but also as precursors for other related medical problems. The characteristic behaviour, identification and product evolution of ß-nicotyrine and 3,5-dimethyl-1-phenylpyrazole in tobacco is reported extensively in this study for the first time. Two commercial cigarette brands coded SM1 and ES1 were explored for evolution of major alkaloids over a modest temperature range of 200 – 700 ° C for a total pyrolysis time of 3 minutes using a tubular quartz reactor, typically in increments of 100 °C using nitrogen as the pyrolysis gas at a residence time of 2.0 seconds under 1 atmosphere pressure. The heating rate of the heater was ~ 20 °C s-1. The pyrolysate was passed over 10 mL analytical grade methanol and analyzed using a Gas-Chromatography hyphenated to a mass spectrometer (GC-MS) with a mass selective detector (MSD). GC-MS results showed that nicotine was the major alkaloid in both cigarettes reaching a maximum at ~ 400 °C (8.0 x 108 GC-Area counts) for ES1 cigarette and 500 °C (~2.7 x 108 GC-Area counts for SM1 cigarette. Clearly, the ratio of nicotine for ES1 to SM1 is approximately 3 indicating that ES1 cigarette is rich in nicotine. Based on this data alone, ES1 cigarette was found to be more addictive.


Cite this article:
C. C. Kurgat, J. K. Kibet, P. K. Cheplogoi, S. C. Limo, P. M. Kimani. Determination of major tobacco alkaloids in mainstream cigarette smoking. Asian J. Research Chem. 2016; 9(5): 205-211. doi: 10.5958/0974-4150.2016.00035.3


Recomonded Articles:

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Anitha Jebamalai Raj, Sudarsanam Dorairaj

DOI:         Access: Open Access Read More

Author(s): Naik YK, Khare A, Choudhary PL, Goel BK, Shrivastava A

DOI:         Access: Open Access Read More

Author(s): Gopalasatheeskumar K, Ariharasiva Kumar G, Sengottuvel T, Sanish Devan V, Srividhya V

DOI: 10.5958/0974-4150.2019.00062.2         Access: Closed Access Read More

Author(s): Salifou Karimoune Fadjimata, Adamou Rabani, Adamou Hassane Hassane, Ayouba Mahamane Abdoulkadri

DOI: 10.5958/0974-4150.2020.00027.9         Access: Closed Access Read More

Author(s): A.K. Meena, M.M. Rao, Kiran Sharma, Ajay Yadav, Uttam Singh, Amit

DOI:         Access: Open Access Read More

Author(s): S Kalidas, B Kameswari, P Devi, B Madhumitha, R Meera, NJ Merlin

DOI:         Access: Open Access Read More

Author(s): Subhasish Chaudhur, Biswajit Chandra Das

DOI:         Access: Open Access Read More

Author(s): Jagadeesh Narkedimilli, Vishweshwar Vavilala, Sandeep Mohanty, Saravanan Manvalan, Jayashree Anireddy

DOI: 10.5958/0974-4150.2018.00096.2         Access: Open Access Read More

Author(s): Sandip N. Badeliya, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): A. K. Meena, A. K. Mangal, M. M. Rao, P. Panda, G. V. Simha, S. K. Shakya, M. M. Padhi, Ramesh Babu

DOI:         Access: Open Access Read More

Author(s): Rukhsana A. Rub, Asma Mukadam, Javed Pinjari, Ajaz Nathani, Aaisha Sagri

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags