ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): T. Raja, A. Lakshmana Rao

Email(s): dralrao@gmail.com

DOI: Not Available

Address: T. Raja1 and A. Lakshmana Rao2*
1Hindu College of Pharmacy, Guntur- 522 002, A.P., India.
2V. V. Institute of Pharmaceutical Sciences, Gudlavalleru- 521 356, A.P., India
*Corresponding Author

Published In:   Volume - 5,      Issue - 10,     Year - 2012


ABSTRACT:
A new simple high performance thin layer chromatographic method for simultaneous determination of levocetirizine dihydrochloride and montelukast sodium in bulk and tablet dosage form was investigated. Chromatographic separation of the drugs were performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of acetone:methanol:toluene (2:2:6 v/v/v). Densitometric evaluation of the separated zones was performed at 240 nm and the method was validated. The Rf values and drug content of levocetirizine dihydrochloride and montelukast sodium were 0.18±0.02, 0.58±0.02 and 100.1%, 99.8% respectively. The calibration curves of peak area versus concentration, which were linear from 50-300 ng per band for levocetirizine dihydrochloride and 100-600 ng per band for montelukast sodium, regression coefficient (r2) was greater than 0.99. The method was validated for linearity, accuracy, robustness and application for assay as per ICH guidelines. The study shows that the developed method is simple and accurate and it would be suitable for the simultaneous determination of levocetirizine dihydrochloride and montelukast sodium in bulk and pharmaceutical formulations.


Cite this article:
T. Raja, A. Lakshmana Rao. Quantitative Analysis of Levocetirizine Dihydrochloride and Montelukast Sodium in Tablets by High Performance Thin Layer Chromatography with Ultra Violet Absorption Densitometry. Asian J. Research Chem. 5(10): October, 2012; Page 1229-1233.


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