ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rajan V. Rele, Prathamesh P. Tiwatane

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-4150.2018.00140.2   

Address: Rajan V. Rele*, Prathamesh P. Tiwatane
Central Research Laboratory, D. G. Ruparel College, Matunga, Mumbai 400016.
*Corresponding Author

Published In:   Volume - 11,      Issue - 5,     Year - 2018


ABSTRACT:
A sensitive and robust novel reverse phase liquid chromatographic method was developed for assay of esomeprazole magnesium trihydrate in its dosage form. For chromatographic study BDS Hypersil C18 (150mm x 4.6mm, 5 µm) was used in on isocratic system at ambient temperature. The selected mobile phase made up of buffer and acetonitrile in proportion 75:25 % (v/v). The flow rate of 1 ml/min. was used in study. The effluent study was done at wavelength 280 nm. The retention time was observed at 3.8 min. The linearity was observed in concentration range as 20 to 60 µg/ml. The correlation coefficient is less than 1. The ICH guidelines were used for system suitability, linearity, accuracy and precision studies. The accuracy and precision were found to be well within the acceptable limit. The method was successfully applied for assay of Esomeprazole magnesium trihydrate in tablets with good recoveries.


Cite this article:
Rajan V. Rele, Prathamesh P. Tiwatane. Validation of Esomeprazole Magnesium Tri-hydrate in Pharmaceutical dosage form by RP-HPLC Method. Asian J. Research Chem. 2018; 11(5):794-798. doi: 10.5958/0974-4150.2018.00140.2

Cite(Electronic):
Rajan V. Rele, Prathamesh P. Tiwatane. Validation of Esomeprazole Magnesium Tri-hydrate in Pharmaceutical dosage form by RP-HPLC Method. Asian J. Research Chem. 2018; 11(5):794-798. doi: 10.5958/0974-4150.2018.00140.2   Available on: https://ajrconline.org/AbstractView.aspx?PID=2018-11-5-5


Recomonded Articles:

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Sravani A

DOI: 10.5958/0974-4150.2018.00144.X         Access: Open Access Read More

Author(s): JR Rao, Mohan Kumar, SS Yadav

DOI:         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Effat Souri, Nazanin Shabani Ravari, Farhad Alvandifar, Arsalan Negahban Aghdami, Maliheh Barazandeh Tehrani, Massoud Amanlou

DOI:         Access: Open Access Read More

Author(s): J Vanitha, A Saravana Kumar, M Ganesh, VS Saravanan

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags