K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S
K. Nagasree1*, Uppalanchi Prashanthi1, Ramya Sri S2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad – 500 007, Telangana, India.
Volume - 16,
Issue - 1,
Year - 2023
Aim of study was to develop bilayer drug delivery for treatment of attention deficit hyperactivity disorder (ADHD) by delivering loading and maintenance dose for fast achievement of peak plasma concentration and maintaining the same respectively. The prepared drug loaded bilayer tablets were evaluated for pre and post compression parameters. The tablets were prepared by direct compression and wet granulation method. The loading dose was delivered in the form of immediate release layer prepared by different super-disintegrations and maintenance dose was delivered through sustained release layer prepared by using polymers like Ethyl cellulose and Carbopol. Both the immediate release layer and sustained release layers were separately optimized and then combined to optimize the bilayer tablets. No interactions were found between drug and excipients. Formulation containing Cross Carmellose shows immediate drug release. Formulation Containing Carbopol shows sustained release action and bilayer formulations F5 shows releases up to 12 hours. Bilayer tablets with release characteristics offer critical advantages such as, site specificity with improved absorption and efficacy.
Cite this article:
K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S, Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets. Asian Journal of Research in Chemistry. 2023; 16(1):91-6. doi: 10.52711/0974-4150.2023.00015
K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S, Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets. Asian Journal of Research in Chemistry. 2023; 16(1):91-6. doi: 10.52711/0974-4150.2023.00015 Available on: https://ajrconline.org/AbstractView.aspx?PID=2023-16-1-15
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