Author(s):
K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S
Email(s):
nagasreepharmacy@gmail.com
DOI:
10.52711/0974-4150.2023.00015 
Address:
K. Nagasree1*, Uppalanchi Prashanthi1, Ramya Sri S2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad – 500 007, Telangana, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2023
ABSTRACT:
Aim of study was to develop bilayer drug delivery for treatment of attention deficit hyperactivity disorder (ADHD) by delivering loading and maintenance dose for fast achievement of peak plasma concentration and maintaining the same respectively. The prepared drug loaded bilayer tablets were evaluated for pre and post compression parameters. The tablets were prepared by direct compression and wet granulation method. The loading dose was delivered in the form of immediate release layer prepared by different super-disintegrations and maintenance dose was delivered through sustained release layer prepared by using polymers like Ethyl cellulose and Carbopol. Both the immediate release layer and sustained release layers were separately optimized and then combined to optimize the bilayer tablets. No interactions were found between drug and excipients. Formulation containing Cross Carmellose shows immediate drug release. Formulation Containing Carbopol shows sustained release action and bilayer formulations F5 shows releases up to 12 hours. Bilayer tablets with release characteristics offer critical advantages such as, site specificity with improved absorption and efficacy.
Cite this article:
K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S, Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets. Asian Journal of Research in Chemistry. 2023; 16(1):91-6. doi: 10.52711/0974-4150.2023.00015
Cite(Electronic):
K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S, Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets. Asian Journal of Research in Chemistry. 2023; 16(1):91-6. doi: 10.52711/0974-4150.2023.00015 Available on: https://ajrconline.org/AbstractView.aspx?PID=2023-16-1-15
REFERENCES:
1. Dr. Y. Krishna Reddy, Ch. Asha. Formulation and Evaluation of Oral Controlled Release Matrix Tablets of Propranolol Hydrochloride. Asian J. Pharm. Res. 2020; 10(2):81-85. doi: 10.5958/2231-5691.2020.00015.5
2. hankar B. Kalbhare, Vivek Kumar Redasani, Mandar J. Bhandwalkar, Rohit K. Pawar, Avinash M. Bhagwat. Role of Aminated derivatives of Natural Gum in Release Modulating Matrix Systems of Losartan Potassium: Optimization of Formulation using Box-Behnken Design. Asian Journal of Pharmaceutical Research. 2021; 11(2):73-4. doi: 10.52711/2231-5691.2021.00015
3. Soujanya Kumari, Ravi Kumar, Yamunappa, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB. Formulation and Evaluation of Gastro Retentive Matrix Tablets of Sitagliptin. Asian J. Res. Pharm. Sci. 6(1): Jan.-Mar., 2016; Page 1-14. doi: 10.5958/2231-5659.2016.00001.1
4. Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur. Design and Characterization of Sustained Release Aceclofenac Matrix Tablets Containing Tamarind Seed Polysaccharide. Asian J. Pharm. Tech. 1(1): Jan.-Mar. 2011; Page 17-21.
5. Poonam R. Songire, Smita S. Aher, R. B. Saudagar. Recent Research on Matrix Tablets for Controlled Release – A Review. Asian J. Pharm. Tech. 2015; Vol. 5( 4): 214-221. doi: 10.5958/2231-5713.2015.00031.8
6. Godbole Ajeet Madhukar, Patel Bhautik V, Somnache Sandesh Narayan, Prajapati Ashish R, Yadav Pradeep. Optimization of Various Grades of HPMC for Development of Sustained Release Matrix Tablets of Theophylline. Asian J. Pharm. Tech. 2017; 7(1): 19-26. doi: 10.5958/2231-5713.2017.00004.6
7. Dr. Y. Krishna Reddy, A. Nagaraju. Formulation and In vitro Evaluation of Sustained Release Matrix Tablet of Azathioprine. Asian J. Pharm. Tech. 2020; 10(2):65-70. doi: 10.5958/2231-5713.2020.00013.6
8. A. Bhavani, B. Hemalatha, K. Padmalatha. Formulation development and in vitro Evaluation of sustained release matrix tablets of Cefpodoxime proxetil. Asian Journal of Pharmacy and Technology. 2021; 11(4):273-8. doi: 10.52711/2231-5713.2021.00045.
9. Shyamala Bhasakran, Preethi Sudheer. Minitablet: A Novel Approach for Oral Extended Release. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):263-268.
10. Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel. Design and Evaluation of Sustained Release Matrix Tablets of Ibuprofen. Research J. Pharma. Dosage Forms and Tech. 2011; 3(4):142-147.
11. Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali. Formulation and In-Vitro Evaluation of In-lay Matrix Tablets Containing Telmisartan and Hydrochlorothiazide. Res. J. Pharm. Dosage Form. and Tech. 7(3): July-Sept., 2015; Page 193-198. doi: 10.5958/0975-4377.2015.00029.4
12. Bilayer Tablets – A Review of State of Art. Svapnil Sanghavi, Misam Polara, Manish Patel, Jayvadan Patel, Niral Shah. Research J. Pharma. Dosage Forms and Tech. 2012; 4(3): 160-165.
13. Mayuri B. Patil, Priyanka M. Salve, Shital V. Sonawane, Avish D. Maru, Jayshree S. Bhadane, Rajendra K. Surawase. Technologies in Bilayer Tablet Manufacturing: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):253-258. doi: 10.52711/0975-4377.2021.00042