ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): M. Jagadeeswaran, N. Gopal, T. Sivakumar

Email(s): jaganmurugesh@gmail.com

DOI: Not Available

Address: M. Jagadeeswaran*, N. Gopal2 and T. Sivakumar1
1Department of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, Tamil Nadu, India
2Department of Pharmaceutical Chemistry, Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal-506 331, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
A simple, selective and rapid reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous estimation of Amlodipine Besylate and Nebivolol Hydrochloride from their tablet formulation. The method is carried out on a nucleosil C18 (25 cm×4.6 mm) column with the mobile phase consisting of 0.01M tetra butyl ammonium hydrogen sulphate: acetonitrile (60:40 v/v) and adjusted the pH to 3.0 by using trimethyl amine, at the flow rate of 1.0 ml min-1. Detection is performed at 264 nm. The retention time of Amlodipine Besylate and Nebivolol Hydrochloride was 2.55 and 5.44 min respectively. The developed method was validated for linearity, accuracy, precision, solution stability, robustness, limit of detection, and limit of quantification. The proposed method can be used for routine analysis of drugs in combined dosage forms.


Cite this article:
M. Jagadeeswaran, N. Gopal, T. Sivakumar. Simultaneous Estimation and Validation of Amlodipine Besylate and Nebivolol Hydrochloride in Tablet Formulation by RP-HPLC Method. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 640-642.


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