Author(s):
P. Suresh, Konda Ravi Kumar
Email(s):
su143ss@gmail.com
DOI:
10.52711/0974-4150.2021.00035 
Address:
P. Suresh1*, Konda Ravi Kumar2
1Vishwa Bharathi College of Pharmaceutical Sciences, Perecharla-522009, A.P., India.
2Department of Pharmaceutical Chemistry, Hindu college of Pharmacy, Guntur, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2021
ABSTRACT:
The aim of the present work is to develop and establish a validated analytical method for the determination of arsenic, cadmium, mercury, lead and palladium content in testosterone propionate by using inductive coupled plasma mass spectroscopy (ICP-MS). Samples were analyzed after a preparation of sample solution by dissolving in suitable solvents of concentrated nitric acid and concentrated hydrochloric acid. In the present method, RF power of 1550 watts, RF matching is 1.80 V, nebulizer flow of 0.10 rps and plasma view at spectrum mode were used. Octopole conditions are He flow is on, He flow rate is 4.3 mL/min and energy discrimination is 3.0 V were used. Significant savings in sample volumes, reagents, analysis cost and time are realized. Arsenic, cadmium, mercury, lead and palladium are primary concerned due to their high toxicity and potential contaminants should be limited in testosterone propionate and the developed method was validated according to ICH and USP guidelines. The correlation coefficient, recovery rate, LOD and LOQ reached the acceptable limits. The validated method was selective, sensitive, rapid and capable of the determination of elemental impurities of arsenic, cadmium, mercury, lead and palladium content in bulk drugs.
Cite this article:
P. Suresh, Konda Ravi Kumar. Determination of elemental impurities of Arsenic, Cadmium, Mercury, Lead and Palladium content in Testosterone propionate by using ICP-MS. Asian Journal of Research in Chemistry. 2021; 14(3):195-2. doi: 10.52711/0974-4150.2021.00035
Cite(Electronic):
P. Suresh, Konda Ravi Kumar. Determination of elemental impurities of Arsenic, Cadmium, Mercury, Lead and Palladium content in Testosterone propionate by using ICP-MS. Asian Journal of Research in Chemistry. 2021; 14(3):195-2. doi: 10.52711/0974-4150.2021.00035 Available on: https://ajrconline.org/AbstractView.aspx?PID=2021-14-3-7
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