Author(s):
Manas Ranjan Sahoo, Ramesh Raghava Varier, Anithakumar Rajendran, Ramesh K.
Email(s):
manasranjansahoo09@yahoo.com
DOI:
10.52711/0974-4150.2023.00022
Address:
Manas Ranjan Sahoo*, Ramesh Raghava Varier, Anithakumar Rajendran, Ramesh K.
AVN Ayurveda Formulation Pvt Ltd, Quality Control and Research and Development Department,
Madurai, Tamil Nadu, India, 625004.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2023
ABSTRACT:
The Ayurvedic medicines are having great therapeutic application due to their natural holistic way of treatment of the disease. To ensure the effectiveness of the medicine standardization of the drug essential. Ayurvedic tailam is an important group of formulations used for treatment of various types of diseases. The principle of using tailam is better absorption of active ingredients by skin when applied through a lipophilic vehicle like vegetable oils. Marichadi Tailam is a herbal oil used for treatment of skin diseases such as eczema and dermatitis. In the present study, an attempt was made to develop and validate a HPTLC method for quantitative determination piperine in the Marichadi coconut oil and its standardization. The HTPLC separation was performed on precoated silica gel 60 F254 aluminum plate (10 × 10cm, 250µm thickness) using toluene:ethyl acetate:diethyl amine (7:2:1) as a mobile phase. The detection and quantification was performed at 340nm. The formulation contains 2.35% of piperine. Linearity studies indicated piperine in the linear ranges, while recovery studies revealed 99.32% (w/w) of piperine. The developed HPTLC method resolved and quantified piperine effectively, so it could be used as a simple reliable method for QC of polyherbal formulations.
Cite this article:
Manas Ranjan Sahoo, Ramesh Raghava Varier, Anithakumar Rajendran, Ramesh K.. Standardization and Quality Control Analysis of Marichadi tailam: An Ayurvedic Formulation. Asian Journal of Research in Chemistry 2023; 16(2):133-8. doi: 10.52711/0974-4150.2023.00022
Cite(Electronic):
Manas Ranjan Sahoo, Ramesh Raghava Varier, Anithakumar Rajendran, Ramesh K.. Standardization and Quality Control Analysis of Marichadi tailam: An Ayurvedic Formulation. Asian Journal of Research in Chemistry 2023; 16(2):133-8. doi: 10.52711/0974-4150.2023.00022 Available on: https://ajrconline.org/AbstractView.aspx?PID=2023-16-2-6
REFERENCES:
1. Roy U, David B, Stefan G, Sabine G. Botanical ingredient identification and quality assessment: strengths and limitations of analytical techniques. Phytochemistry Reviews volume (Phytochem Rev.). 2020; 19: 1157-77.
2. Jon CT, Ted JK. Herbal medicine research and global health: an ethical analysis. Bull World Health Organ. 2008; 86(8): 594-9.
3. Sen S, Chakraborty R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future. J Tradit Complement Med. 2017; 7(2):234–244.
4. Li Y, Shen Y, Yao C-liang, Guo D-an, Quality assessment of herbal medicines based on chemical fingerprints combined with chemometrics approach: A review. Journal of Pharmaceutical and Biomedical Analysis. 20205; 185:113215.
5. WHO. Guidelines for assessing quality of herbal medicines with reference to contaminants and residues. Geneva: World Health Organization; 2007.
6. Jaiswal S, Chavhan SA, Shinde SA, Wawge NK. New Tools for Herbal Drug Standardization. Asian J. Res. Pharm. Sci. 2018; 8(3): 161-169.
7. Patel U, Girme A, Patel K, Ghule C, Lal H, Gandhi T.A validated HPTLC method for quantification of cordifolioside A, 20‑β‑hydroxyecdysone and columbin with HPTLC–ESI–MS/MS characterization in stems of Tinospora cordifolia. JPC-Journal of Planar Chromatography-Modern TLC. 2021; 34:217-28.
8. Bhakti JL, Vijay MM, Urmi DK, Rina HG. Marker based standardization of polyherbal formulation (SJT-DI-02) by high performance thin layer chromatography method. J Pharm Bioallied Sci. 2014; 6(3): 213-9.
9. Jain V, Jain T, Saraf S. HPTLC method for routine quality control of Ayurvedic formulation Drakshadi gutika. Asian Journal of Pharmaceutical Analysis. J. Pharm. Ana. 2013; 3(4):111-4.
10. Arivukkarasu A, Rajasekaran A. Detection and Quantification of Anti-oxidant markers like Rutin, Catechin, Quercetin, Gallic acid, Ellagic acid, Ferulic acid, Vitexin and Mangiferin in Herbal raw materials available in market belongs to Rutaceae family by HPTLC Technique. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):151-5.
11. Ghumare P, Dolas RT, Aher V. Development of HPTLC Method for the Estimation of Andrgrapholide from Arjuna Tablet. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):156-8.
12. Rawat S, Gupta A. Development of Novel HPTLC Method for Estimation of Qurcetine in Ocimum sanctum. Asian J. Pharm. Tech. 1(4): Oct. - Dec. 2011; Page 149-151.
13. Kaviarasan L, Sarojini S, Yoganandam PG, Gopal V. Preparation and Standardization of Deepavali Avaleha - A Traditional Polyherbal Ayurvedic Formulation. Asian J. Pharm. Tech. 2016; 6(4): 231-237.
14. Sharma R, Kumari N, Ashawat MS, Verma CPS. Standardization and Phytochemical Screening analysis for Herbal Extracts: Zingiber officinalis, Rosc., Curcuma longa Linn., Cinnamonum zeylanicum Nees., Piper longum, Linn., Boerhaavia diffussa Linn. Asian J. Pharm. Tech. 2020; 10(3):127-133.
15. Yeotkar US, Nimbhorkar M, Deshmukh TA, Patil VR. Quantitative Estimation of Piperine in Ayurvedic Formulations by HPTLC. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 898-902.
16. Rohan RV, Talokar S, Dhole AR, Mohite SK, Magdum CS. Comparative Standardization Study of Two Marketed Shatavari Churna Formulation. Asian J. Pharm. Ana. 2016; 6(1):1-6.
17. 17. Singh N, Chaudhary A.A comparative review study of Sneha Kalpana (Paka) vis-a-vis liposome. Ayu. 2011; 32(1):103-8.